Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry

J Med Chem. 2011 Mar 24;54(6):1539-54. doi: 10.1021/jm101356p. Epub 2011 Feb 23.

Authors

Minoru Ishikawa¹, Yuichi Hashimoto

Affiliation

¹ Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. m-ishikawa@iam.u-tokyo.ac.jp

PMID: 21344906
DOI: 10.1021/jm101356p

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Databases, Factual
Drug Discovery*
Hydrophobic and Hydrophilic Interactions
Molecular Structure*
Pharmaceutical Preparations / chemistry*
Solubility
Structure-Activity Relationship
Thermodynamics
Water / chemistry*

Substances

Pharmaceutical Preparations
Water